P816 The efficacy of an over the counter multivitamin and mineral supplement to prevent opportunistic infections in patients with inflammatory bowel disease in remission

Abstract Background Patients with inflammatory bowel disease (IBD) treated immunomodulators or biological therapy are at increased risk of infections. Malnutrition and vitamin mineral deficiencies common among patients IBD. The results various studies have indicate that might increase the Methods Single-centre, randomized, double-blinded, placebo-controlled clinical trial to compare a multivitamin supplement (vitamin group) versus identical in appearance placebo (placebo group). Crohn’s ulcerative colitis using and/or without deficiency were considered for participation our study. Participants asked take daily report occurrence infections during 24 weeks period follow up. primary endpoint this study was difference incidence infection between two groups measured by validated questionnaire, revised version ID screen assess infection13. Randomization conducted computer generated random numbers an allocation ratio 1:1 blocks 8 stratified according type IBD.Results Between July 2020 February 2021, 320 randomized. Treatment arms consisted out 162 158 placebo, respectively. Both showed similarity patient characteristics. All included intention-to -Treat (ITT), 265 per protocol (PP) (compliance >80%) analyses. For both groups, 107 reported up (Unadjusted Odds Ratio: 0.93 (95% confidence interval: 0.56-1.48). In group, 32 received antibiotics compared 21 group 1.61 0.88-2.93). 166 PP analysis 0.91 0.55-1.50), 23 serious 2.57 1.02 -6.46). None hospitalized due infection. Conclusion An over counter did not reduce IBD remission therapy.